Journal of Hematology & Oncology (2024)

A single-cell and spatially resolved atlas of human osteosarcomas

Osteosarcomas are intricate cellular ecosystems, where heterotypic interactions significantly influence disease progression and therapeutic outcomes. Despite their importance, a detailed understanding of their...

Authors: Xuejing Zheng, Xu Liu, Xinxin Zhang, Zhenguo Zhao, Wence Wu and Shengji Yu

Citation: Journal of Hematology & Oncology 2024 17:71

Content type: Correspondence Published on: 20 August 2024

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Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients

Deletions and partial losses of chromosome 7 (chr7) are frequent in acute myeloid leukemia (AML) and are linked to dismal outcome. However, the genomic landscape and prognostic impact of concomitant genetic ab...

Authors: Adriane Halik, Marlon Tilgner, Patricia Silva, Natalia Estrada, Robert Altwasser, Ekaterina Jahn, Michael Heuser, Hsin-An Hou, Marta Pratcorona, Robert K. Hills, Klaus H. Metzeler, Laurene Fenwarth, Anna Dolnik, Christine Terre, Klara Kopp, Olga Blau…

Citation: Journal of Hematology & Oncology 2024 17:70

Content type: Research Published on: 19 August 2024

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Comparisons of treatment outcomes of epcoritamab versus chemoimmunotherapy, polatuzumab-based regimens, tafasitamab-based regimens, or chimeric antigen receptor T-cell therapy, in third-line or later relapsed/refractory large B-cell lymphoma

Many therapies are available for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) after ≥ 2 lines of therapy, albeit with scant evidence on the comparative effectiveness of thes...

Authors: Allison Rosenthal, Javier Munoz, Monika Jun, Tongsheng Wang, Alex Mutebi, Anthony Wang, Shibing Yang, Kojo Osei-Bonsu, Brian Elliott, Fernando Rivas Navarro, Junhua Yu, Samantha Brodkin, Mariana Sacchi and Andrew Ip

Citation: Journal of Hematology & Oncology 2024 17:69

Content type: Correspondence Published on: 16 August 2024

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Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives

Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltra...

Authors: Chenliang Zhang, Tingting Huang and Liping Li

Citation: Journal of Hematology & Oncology 2024 17:68

Content type: Review Published on: 16 August 2024

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IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providin...

Authors: Yi Zhang, Miso Park, Lucy Y. Ghoda, Dandan Zhao, Melissa Valerio, Ebtesam Nafie, Asaul Gonzalez, Kevin Ly, Bea Parcutela, Hyeran Choi, Xubo Gong, Fang Chen, Kaito Harada, Zhenhua Chen, Le Xuan Truong Nguyen, Flavia Pichiorri…

Citation: Journal of Hematology & Oncology 2024 17:67

Content type: Research Published on: 14 August 2024

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LncRNA-encoded peptides in cancer

Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs have revealed that certain ...

Authors: Yaguang Zhang

Citation: Journal of Hematology & Oncology 2024 17:66

Content type: Review Published on: 12 August 2024

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Recent developments in immunotherapy for gastrointestinal tract cancers

The past few decades have witnessed the rise of immunotherapy for Gastrointestinal (GI) tract cancers. The role of immune checkpoint inhibitors (ICIs), particularly programmed death protein 1 (PD-1) and PD lig...

Authors: Xiaoyi Chong, Yelizhati Madeti, Jieyuan Cai, Wenfei Li, Lin Cong, Jialin Lu, Liyang Mo, Huizhen Liu, Siyi He, Chao Yu, Zhiruo Zhou, Boya Wang, Yanshuo Cao, Zhenghang Wang, Lin Shen, Yakun Wang…

Citation: Journal of Hematology & Oncology 2024 17:65

Content type: Review Published on: 9 August 2024

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Correction: lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer

Authors: Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang

Citation: Journal of Hematology & Oncology 2024 17:64

Content type: Correction Published on: 9 August 2024

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Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study

Invasive fungal disease (IFD) presents a life-threatening condition in immunocompromised patients, thus often prompting empirical administration of antifungal treatment, without adequate mycological evidence. ...

Authors: Chantal Lucini, Klára Obrová, Isabella Krickl, Filomena Nogueira, Iva Kocmanová, Susanne Herndlhofer, Karoline V. Gleixner, Wolfgang R. Sperr, Tijana Frank, Nuno Andrade, Christina Peters, Gernot Engstler, Michael Dworzak, Andishe Attarbaschi, Martine van Grotel, Marry M. van den Heuvel-Eibrink…

Citation: Journal of Hematology & Oncology 2024 17:63

Content type: Correspondence Published on: 7 August 2024

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Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration

Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile...

Authors: Keyu Li, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He…

Citation: Journal of Hematology & Oncology 2024 17:62

Content type: Correspondence Published on: 7 August 2024

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Novel prognostic scoring systems for severe CRS and ICANS after anti-CD19 CAR T cells in large B-cell lymphoma

Autologous anti-CD19 chimeric antigen receptor (CAR) T cells are now used in routine practice for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Severe (grade ≥ 3) cytokine release syndrome (CRS) and ...

Authors: Pierre Sesques, Amy A. Kirkwood, Mi Kwon, Kai Rejeski, Michael D. Jain, Roberta Di Blasi, Gabriel Brisou, François-Xavier Gros, Fabien le Bras, Pierre Bories, Sylvain Choquet, Marie-Thérèse Rubio, Gloria Iacoboni, Maeve O’Reilly, René-Olivier Casasnovas, Jacques-Olivier Bay…

Citation: Journal of Hematology & Oncology 2024 17:61

Content type: Research Published on: 6 August 2024

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Continuous therapy in HHV-8 negative Multicentric Castleman Disease and prolonged progression-free survival

The optimal treatment endpoints and duration of continuous therapy for multicentric Castleman disease (MCD) remain controversial. We retrospectively analyzed data from 123 patients with Human Herpesvirus (HHV)...

Authors: Yi Liu, Xuejiao Yin, Shengnan Ding, Jiaying Ge, Liya Ma, Min Yang, Xuxia Luo, Chengli Zhong, Sishi Fang, Qiumei Yao, Li Zhu, Wenjuan Yu, Liping Mao, Juying Wei, Xingnong Ye, De Zhou…

Citation: Journal of Hematology & Oncology 2024 17:60

Content type: Correspondence Published on: 6 August 2024

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Retraction Note: AMLnet, A deep-learning pipeline for the differential diagnosis of acute myeloid leukemia from bone marrow smears

Authors: Zebin Yu, Jianhu Li, Xiang Wen, Yingli Han, Penglei Jiang, Meng Zhu, Minmin Wang, Xiangli Gao, Dan Shen, Ting Zhang, Shuqi Zhao, Yijing Zhu, Jixiang Tong, Shuchong Yuan, HongHu Zhu, He Huang…

Citation: Journal of Hematology & Oncology 2024 17:59

Content type: Retraction Note Published on: 1 August 2024

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SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing

Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward...

Authors: Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga and Charles M. Rudin

Citation: Journal of Hematology & Oncology 2024 17:58

Content type: Research Published on: 30 July 2024

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Novel natural killer cell-based therapies for hematologic and solid malignancies: latest updates from ASCO 2024

Natural killer (NK) cell-based therapies have made great progress in treating both hematological and solid tumors. Their unique mechanism of action does not rely on antigen presentation to recognize and elimin...

Authors: Xubo Gong, Lianjun Zhang, Xin He, Jing Yang, Xiang Li, Weiwei Liu, Bin Zhang, Zhihua Tao and Wenbin Qian

Citation: Journal of Hematology & Oncology 2024 17:57

Content type: Correspondence Published on: 29 July 2024

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A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC

In 2022, two new classifications of myeloid neoplasms and acute leukemias were published: the 5th edition WHO Classification (WHO-HAEM5) and the International Consensus Classification (ICC). As with prior clas...

Authors: Wenbin Xiao, Valentina Nardi, Eytan Stein and Robert P. Hasserjian

Citation: Journal of Hematology & Oncology 2024 17:56

Content type: Review Published on: 29 July 2024

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Harnessing extracellular vesicles using liquid biopsy for cancer diagnosis and monitoring: highlights from AACR Annual Meeting 2024

Liquid biopsy, an advanced technology for analyzing body fluid samples, is gaining traction in cancer diagnostics and monitoring. Blood-based liquid biopsy, particularly focusing on cell-free DNAs (cf-DNAs), c...

Authors: Xinming Su, Zeping Shan and Shiwei Duan

Citation: Journal of Hematology & Oncology 2024 17:55

Content type: Correspondence Published on: 29 July 2024

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Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer

Cancer immunotherapies, represented by immune checkpoint inhibitors (ICIs), have reshaped the treatment paradigm for both advanced non-small cell lung cancer and small cell lung cancer. Programmed death recept...

Authors: Weishi Cheng, Kai Kang, Ailin Zhao and Yijun Wu

Citation: Journal of Hematology & Oncology 2024 17:54

Content type: Review Published on: 27 July 2024

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Lipid-based nanosystems: the next generation of cancer immune therapy

Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well as its use of endogenous mechanisms to achieve desired ends. However, off...

Authors: Ziyun Cheng, Seth-Frerich Fobian, Elena Gurrieri, Mohamadreza Amin, Vito Giuseppe D’Agostino, Mojtaba Falahati, Sara Zalba, Reno Debets, María J. Garrido, Mesha Saeed, Ann L. B. Seynhaeve, Hayri E. Balcioglu and Timo L. M. ten Hagen

Citation: Journal of Hematology & Oncology 2024 17:53

Content type: Review Published on: 19 July 2024

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Menin inhibitors for acute myeloid leukemia: latest updates from the 2023 ASH Annual Meeting

Recent developments in menin inhibitors for relapsed or refractory acute myeloid leukemia (AML) were highlighted at the 2023 ASH Annual Meeting. Notably, revumenib showed promising efficacy, achieving a 100% O...

Authors: Zhuo-Yu An and Xiao-Hui Zhang

Citation: Journal of Hematology & Oncology 2024 17:52

Content type: Correspondence Published on: 19 July 2024

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Mature B, T and NK-cell, plasma cell and histiocytic/dendritic cell neoplasms: classification according to the World Health Organization and International Consensus Classification

In 2022, two updated classification systems for lymphoid neoplasms were published by the World Health Organization (WHO Classification of Haematolymphoid Tumours, 5th edition, referred to hereafter as WHO-HAEM...

Authors: Judith A. Ferry, Brian Hill and Eric D. Hsi

Citation: Journal of Hematology & Oncology 2024 17:51

Content type: Review Published on: 8 July 2024

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Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial

Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects....

Authors: Swati Naik, Ying Li, Aimee C. Talleur, Subodh Selukar, Emily Ashcraft, Cheng Cheng, Renee M. Madden, Ewelina Mamcarz, Amr Qudeimat, Akshay Sharma, Ashok Srinivasan, Ali Y. Suliman, Rebecca Epperly, Esther A. Obeng, M. Paulina Velasquez, Deanna Langfitt…

Citation: Journal of Hematology & Oncology 2024 17:50

Content type: Research Published on: 27 June 2024

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Advances in CAR-T-cell therapy in T-cell malignancies

Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet ach...

Authors: Rubing Zheng, Xiaojian Zhu and Yi Xiao

Citation: Journal of Hematology & Oncology 2024 17:49

Content type: Review Published on: 24 June 2024

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Individualized dynamic frailty-tailored therapy (DynaFiT) in elderly patients with newly diagnosed multiple myeloma: a prospective study

It remains a substantial challenge to balance treatment efficacy and toxicity in geriatric patients with multiple myeloma (MM), primarily due to the dynamic nature of frailty. Here, we conducted a prospective ...

Authors: Yingjie Zhang, Xinyue Liang, Weiling Xu, Xingcheng Yi, Rui Hu, Xintian Ma, Yurong Yan, Nan Zhang, Jingxuan Wang, Xiaoxiao Sun, Yufeng Zhu, Mengru Tian, Maozhuo Lan, Mengtuan Long, Yun Dai and Fengyan Jin

Citation: Journal of Hematology & Oncology 2024 17:48

Content type: Correspondence Published on: 24 June 2024

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Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study

Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 and KCNA3 were specifically hypermethylated in circulating cell-free DNA from patients ...

Authors: Yan Bian, Ye Gao, Han Lin, Chang Sun, Wei Wang, Siyu Sun, Xiuling Li, Zhijie Feng, Jianlin Ren, Hezhong Chen, Chaojing Lu, Jinfang Xu, Jun Zhou, Kangkang Wan, Lei Xin, Zhaoshen Li…

Citation: Journal of Hematology & Oncology 2024 17:47

Content type: Correspondence Published on: 18 June 2024

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Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation. Under normal physiological conditions, the Wnt...

Authors: Pan Song, Zirui Gao, Yige Bao, Li Chen, Yuhe Huang, Yanyan Liu, Qiang Dong and Xiawei Wei

Citation: Journal of Hematology & Oncology 2024 17:46

Content type: Review Published on: 18 June 2024

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Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant

p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.

Authors: Dafei Chai, Junhao Wang, Chunmei Fan, Jing-Ming Lim, Xu Wang, Praveen Neeli, Xinfang Yu, Ken H. Young and Yong Li

Citation: Journal of Hematology & Oncology 2024 17:45

Content type: Research Published on: 18 June 2024

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Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles in tumour growt...

Authors: Belén Toledo, Linrui Zhu Chen, María Paniagua-Sancho, Juan Antonio Marchal, Macarena Perán and Elisa Giovannetti

Citation: Journal of Hematology & Oncology 2024 17:44

Content type: Review Published on: 11 June 2024

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Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia

Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-...

Authors: Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka…

Citation: Journal of Hematology & Oncology 2024 17:43

Content type: Research Published on: 9 June 2024

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Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel

Idecabtagene vicleucel (Ide-cel) has demonstrated excellent efficacy and durable responses in patients with relapsed/refractory multiple myeloma (RRMM). However, the outcomes with ide-cel in patients with extr...

Authors: Saurabh Zanwar, Surbhi Sidana, Leyla Shune, Omar Castaneda Puglianini, Oren Pasvolsky, Rebecca Gonzalez, Danai Dima, Aimaz Afrough, Gurbakhash Kaur, James A. Davis, Megan Herr, Hamza Hashmi, Peter Forsberg, Douglas Sborov, Larry D. Anderson Jr, Joseph P. McGuirk…

Citation: Journal of Hematology & Oncology 2024 17:42

Content type: Research Published on: 6 June 2024

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Ferroptosis: principles and significance in health and disease

Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-...

Authors: Fangquan Chen, Rui Kang, Daolin Tang and Jiao Liu

Citation: Journal of Hematology & Oncology 2024 17:41

Content type: Review Published on: 6 June 2024

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Current and future immunotherapeutic approaches in pancreatic cancer treatment

Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it is extremely challengi...

Authors: Pooya Farhangnia, Hossein Khorramdelazad, Hamid Nickho and Ali-Akbar Delbandi

Citation: Journal of Hematology & Oncology 2024 17:40

Content type: Review Published on: 4 June 2024

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Targeting FGFR for cancer therapy

The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as...

Authors: Pei Zhang, Lin Yue, QingQing Leng, Chen Chang, Cailing Gan, Tinghong Ye and Dan Cao

Citation: Journal of Hematology & Oncology 2024 17:39

Content type: Review Published on: 3 June 2024

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Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma

Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously challenging to treat and outcomes are typically poor. Over the past two decades, clinical...

Authors: Esther Wei Yin Chang, Ya Hwee Tan and Jason Yongsheng Chan

Citation: Journal of Hematology & Oncology 2024 17:38

Content type: Review Published on: 1 June 2024

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Advances in targeting histone deacetylase for treatment of solid tumors

Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC in...

Authors: Mu-Qi Shi, Ying Xu, Xin Fu, De-Si Pan, Xian-Ping Lu, Yi Xiao and Yi-Zhou Jiang

Citation: Journal of Hematology & Oncology 2024 17:37

Content type: Review Published on: 31 May 2024

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Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening

Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due to various limiting factors. To address this challenge, we engineered an OV containing...

Authors: Yiye Zhong, Huangying Le, Xue Zhang, Yao Dai, Fang Guo, Xiaojuan Ran, Guohong Hu, Qi Xie, Dawei Wang and Yujia Cai

Citation: Journal of Hematology & Oncology 2024 17:36

Content type: Correspondence Published on: 23 May 2024

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Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment

Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or lymphatic endothelial cells; its low incidence has posed significant challenges for comprehensive investigations into its patho...

Authors: Da Jung Jung, Jae Hee Byeon, Young Chul Kim, Woo Shik Jeong, Jong-Woo Choi and Gi Seok Jeong

Citation: Journal of Hematology & Oncology 2024 17:35

Content type: Correspondence Published on: 20 May 2024

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PD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation

Disseminated adenovirus infection is a complication with a relatively high mortality rate among patients undergoing hematopoietic stem cell transplantation. The low efficacy and poor availability of current tr...

Authors: Fei Zhou, Feng Du, Ziyan Wang, Mengxing Xue, Depei Wu, Suning Chen and Xuefeng He

Citation: Journal of Hematology & Oncology 2024 17:34

Content type: Correspondence Published on: 20 May 2024

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Critical role of the gut microbiota in immune responses and cancer immunotherapy

The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cance...

Authors: Zehua Li, Weixi Xiong, Zhu Liang, Jinyu Wang, Ziyi Zeng, Damian Kołat, Xi Li, Dong Zhou, Xuewen Xu and Linyong Zhao

Citation: Journal of Hematology & Oncology 2024 17:33

Content type: Review Published on: 14 May 2024

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Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions

Inotuzumab ozogamicin (INO) is an anti-CD22 antibody-drug conjugate that was first evaluated in B-cell lymphomas but was subsequently shown to be highly effective in acute lymphoblastic leukemia (ALL). INO imp...

Authors: Nicholas J. Short, Elias Jabbour, Nitin Jain and Hagop Kantarjian

Citation: Journal of Hematology & Oncology 2024 17:32

Content type: Review Published on: 11 May 2024

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Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive microenvironment, thereby confounding conventional therapeutic interventi...

Authors: Hao Lin, Chaxian Liu, Ankang Hu, Duanwu Zhang, Hui Yang and Ying Mao

Citation: Journal of Hematology & Oncology 2024 17:31

Content type: Review Published on: 8 May 2024

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Small molecule inhibitors targeting m6A regulators

As the most common form of epigenetic regulation by RNA, N⁶ methyladenosine (m⁶A) modification is closely involved in physiological processes, such as growth and development, stem cell renewal and differentiation...

Authors: Guotai Feng, Yongya Wu, Yuan Hu, Wen Shuai, Xiao Yang, Yong Li, Liang Ouyang and Guan Wang

Citation: Journal of Hematology & Oncology 2024 17:30

Content type: Review Published on: 6 May 2024

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Off-the-shelf CAR-T cell therapies for relapsed or refractory B-cell malignancies: latest update from ASH 2023 annual meeting

Currently, many off-the-shelf chimeric antigen receptor (CAR)-T cell products are under investigation for the treatment of relapsed or refractory (R/R) B-cell neoplasms. Compared with autologous CAR-T cell the...

Authors: Yun Kang, Chenggong Li and Heng Mei

Citation: Journal of Hematology & Oncology 2024 17:29

Content type: Correspondence Published on: 6 May 2024

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Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model

Patients with cytogenetically normal acute myeloid leukemia (CN-AML) may harbor prognostically relevant gene mutations and thus be categorized into one of the three 2022 European LeukemiaNet (ELN) genetic-risk...

Authors: Kellie J. Archer, Han Fu, Krzysztof Mrózek, Deedra Nicolet, Alice S. Mims, Geoffrey L. Uy, Wendy Stock, John C. Byrd, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Klaus H. Metzeler, Tobias Herold and Ann-Kathrin Eisfeld

Citation: Journal of Hematology & Oncology 2024 17:28

Content type: Correspondence Published on: 3 May 2024

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ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity

The rapid advancements in large language models (LLMs) such as ChatGPT have raised concerns about their potential impact on academic integrity. While initial concerns focused on ChatGPT’s writing capabilities,...

Authors: Lingxuan Zhu, Yancheng Lai, Weiming Mou, Haoran Zhang, Anqi Lin, Chang Qi, Tao Yang, Liling Xu, Jian Zhang and Peng Luo

Citation: Journal of Hematology & Oncology 2024 17:27

Content type: Correspondence Published on: 1 May 2024

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Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study

Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling pathway, which repairs DNA interstrand crosslinks, represent risk factors for common can...

Authors: Svenja Kastellan, Reinhard Kalb, Bia Sajjad, Lisa J. McReynolds, Neelam Giri, David Samuel, Till Milde, Miriam Elbracht, Susanne Holzhauer, Marena R. Niewisch and Christian P. Kratz

Citation: Journal of Hematology & Oncology 2024 17:26

Content type: Correspondence Published on: 29 April 2024

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Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives

Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made g...

Authors: Ke-Yu Shen, Ying Zhu, Sun-Zhe Xie and Lun-Xiu Qin

Citation: Journal of Hematology & Oncology 2024 17:25

Content type: Review Published on: 29 April 2024

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A higher CD34 + cell dose correlates with better event-free survival after KIR-ligand mismatched cord blood transplantation for childhood acute myeloid leukemia

Although killer Ig-like receptor ligands (KIR-L) mismatch has been associated with alloreactive natural killer cell activity and potent graft-versus-leukemia (GVL) effect among adults with acute myeloid leukem...

Authors: Hisashi Ishida, Yuta Kawahara, Daisuke Tomizawa, Yasuhiro Okamoto, Asahito Hama, Yuko Cho, Katsuyoshi Koh, Yuhki Koga, Nao Yoshida, Maho Sato, Kiminori Terui, Naoyuki Miyagawa, Akihiro Watanabe, Junko Takita, Ryoji Kobayashi, Masaki Yamamoto…

Citation: Journal of Hematology & Oncology 2024 17:24

Content type: Correspondence Published on: 29 April 2024

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Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial

The autologous anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy LCAR-B38M has been approved for the treatment of relapsed and refractory multiple myeloma in many countries a...

Authors: Jie Xu, Bai-Yan Wang, Shan-He Yu, Shi-Jun Chen, Shuang-Shuang Yang, Rui Liu, Li-Juan Chen, Jian Hou, Zhu Chen, Wan-Hong Zhao, Ai-Li He, Jian-Qing Mi and Sai-Juan Chen

Citation: Journal of Hematology & Oncology 2024 17:23

Content type: Research Published on: 24 April 2024

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Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma

Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma (LBCL), yet biomarkers that predict outcomes and toxicity are lacking. We examined rad...

Authors: Doris Leithner, Jessica R. Flynn, Sean M. Devlin, Audrey Mauguen, Teng Fei, Shang Zeng, Junting Zheng, Brandon S. Imber, Harper Hubbeling, Marius E. Mayerhoefer, Akshay Bedmutha, Efrat Luttwak, Magdalena Corona, Parastoo B. Dahi, Alejandro Luna de Abia, Ivan Landego…

Citation: Journal of Hematology & Oncology 2024 17:21

Content type: Correspondence Published on: 23 April 2024

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